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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
07:30

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

Published on: January 21, 2020

7-azaindole as privileged scaffold: Advances in drug design and structural modification

Yichun Shi1, Guangjun Yu2, Yidan Xu3

  • 1Department of Medicinal Chemistry, Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.

Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents
|July 23, 2026
PubMed
Summary

7-azaindole is a versatile scaffold in drug design, offering improved properties over indole. This review covers recent advances (2020-2026) in 7-azaindole therapeutics, focusing on SAR trends and clinical outcomes.

Keywords:
7-azaindoleAnti-infectionAnticancerFragment-based drug discoveryKinase inhibitorsStructure-activity relationship

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