Pilomatricomal Horn With Confirmed CTNNB1 Mutation: A Rarely Reported Follicular Tumor
Maged Daruish1,2, Saleem Taibjee1,2
1Cellular Pathology Department, Dorset County Hospital NHS Foundation Trust, Dorchester, United Kingdom; and.
The American Journal of Dermatopathology
|July 23, 2026
Abstract:
Pilomatricoma is a benign adnexal neoplasm of matrical follicular differentiation, typically arising in the dermis or subcutis. CTNNB1 gene mutations are well recognized in pilomatricomas. Herein, we describe a rare epidermal-based pilomatricomal lesion that clinically presented with a cutaneous horn, previously reported in the literature as pilomatricomal horn. We have also identified a CTNNB1 mutation by next-generation sequencing in our case, supporting its relationship with pilomatricoma.
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