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Updated: Aug 6, 2026
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Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
Published on: December 9, 2010
Icosahedral Boron Clusters as Platforms for Biomedical Applications: From Cellular Bioimaging to In Vivo Theranostics
Javier Ordóñez-Hernández1, Rosario Núñez2
1Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Carrer dels Til.lers, Cerdanyola del Vallès, Spain.
Handbook of Experimental Pharmacology
|July 25, 2026
Summary
Icosahedral boron clusters are advanced biomedical platforms for integrated cancer imaging and therapy. These stable, adaptable boron clusters enable precise diagnosis and treatment, particularly for boron neutron capture therapy (BNCT).
Area of Science:
- Nanomedicine
- Bioconjugate Chemistry
- Nuclear Medicine
Background:
- Icosahedral boron clusters offer unique properties like high boron density and stability for biomedical applications.
- Their adaptability allows for the creation of multifunctional agents for combined diagnosis and treatment.
- Boron neutron capture therapy (BNCT) is a promising cancer treatment modality.
Purpose of the Study:
- To review the biomedical applications of icosahedral boron clusters for cellular bioimaging and in vivo theranostics.
- To emphasize the role of boron clusters in boron neutron capture therapy (BNCT).
- To highlight advancements in integrated imaging, dosimetry, and therapy for personalized cancer treatment.
Main Methods:
- Incorporation of boron clusters into fluorescent probes and photoactive conjugates for in vitro studies.
- Development of Gadolinium-carborane systems for MRI-guided BNCT and GdNCT.
- Utilizing PET/SPECT-radiolabeled boron clusters for biodistribution tracking and dosimetry.
- Designing targeted and nanostructured formulations for improved tumor selectivity.
Main Results:
- In vitro studies demonstrate control over BNCT and photodynamic efficacy through subcellular localization.
- In vivo studies show successful MRI-guided BNCT and GdNCT using evolving nanoplatforms and targeted molecules.
- Radiolabeled boron clusters enable quantitative tracking for patient selection and treatment timing.
- Targeted and nanostructured boron cluster formulations enhance therapeutic efficacy and reduce toxicity.
Conclusions:
- Icosahedral boron clusters have evolved into clinically relevant theranostic platforms.
- These platforms integrate imaging, dosimetry, and therapy for precise cancer diagnosis and treatment.
- Boron cluster-based theranostics support the development of personalized cancer care strategies.
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