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Updated: Aug 5, 2026

A Minimally Invasive Method for Intratracheal Instillation of Drugs in Neonatal Rodents to Treat Lung Disease
04:21

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Published on: August 4, 2021

MEK Inhibitor Associated Airway Injury in an Infant With Noonan Syndrome: A Case Report

Veronica Drozdowski-Nuccio1,2, Rachel D Yoon3, Steven Tomasi1

  • 1Division of Pediatric Otolaryngology-Head and Neck Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.

The Laryngoscope
|July 26, 2026
PubMed
Summary

Trametinib, a MEK inhibitor, caused airway mucosal sloughing and scarring in an infant with Noonan syndrome. This highlights the potential for airway toxicity with MEK inhibitor therapies.

Keywords:
MEK inhibitorNoonan syndromesevere side effectstoxicitytrametinib

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