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MEK Inhibitor Associated Airway Injury in an Infant With Noonan Syndrome: A Case Report
Veronica Drozdowski-Nuccio1,2, Rachel D Yoon3, Steven Tomasi1
1Division of Pediatric Otolaryngology-Head and Neck Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
The Laryngoscope
|July 26, 2026
Abstract:
An infant with Noonan syndrome treated with trametinib developed extensive mucosal sloughing of the upper and lower airway, followed by severe supraglottic scarring. Clinicians should consider airway toxicity as a potential adverse effect of MEK inhibitor therapy.