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Biomimetic Surface Engineering of Ti-15Zr (Roxolid™) Implants: Enhancing Osseointegration and Bone Regeneration-A
Antonio Libonati1,2, Danilo Marroni2, Giulio Barbalace2
1Dental School, Catholic University of Our Lady of Good Counsel, 1000 Tirana, Albania.
Biomimetics (Basel, Switzerland)
|July 27, 2026
Summary
Dental implants using Ti-15Zr (Roxolid™) alloys combined with biomimetic surface engineering accelerate bone healing. This approach enhances osseointegration, improving outcomes for patients with compromised bone quality.
Area of Science:
- Biomaterials Science
- Dental Implantology
- Regenerative Medicine
Background:
- Titanium-15% Zirconium (Ti-15Zr) alloys offer superior mechanical properties for dental implants.
- Osseointegration in compromised bone sites remains a clinical challenge.
- Biomimetic surface engineering aims to replicate the bone extracellular matrix (ECM).
Purpose of the Study:
- To review the synergy between Ti-15Zr substrates and biomimetic surface modifications.
- To synthesize evidence on architectural, mechanical, and biochemical integration strategies.
- To evaluate the impact on osseointegration and bone regeneration.
Main Methods:
- Narrative literature synthesis of studies from 2010-2026.
- Searches conducted in PubMed, Scopus, and Web of Science.
- Focus on studies combining Ti-15Zr alloys with surface engineering techniques.
Main Results:
- High fatigue strength of Ti-15Zr (Roxolid™) supports advanced surface modifications.
- Hierarchical surface engineering (macro/nano-topography) enhances primary stability and protein adsorption.
- Bio-functionalization with peptides and ions promotes mesenchymal stem cell (MSC) differentiation.
Conclusions:
- Biomimetic engineering of Ti-15Zr implants creates instructive biological platforms.
- This synergy accelerates osseointegration and bridges the early healing "biological gap".
- Improved outcomes are expected for patients with poor bone quality, enabling immediate loading.