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Neurokinin 3 Receptor Antagonists for Menopause Symptom Management
Laura L Faubion1, Jana Karam2, Caroline P Tatit3
1Department of Obstetrics and Gynecology, Marian Regional Medical Center, Santa Maria, CA, USA.
Obstetrics and Gynecology Clinics of North America
|July 27, 2026
Summary
Neurokinin receptor antagonists offer effective nonhormonal relief for vasomotor symptoms (VMS). Elinzanetant and fezolinetant show promise, with elinzanetant also improving sleep and supporting use in breast cancer patients.
Area of Science:
- Neuroscience
- Pharmacology
- Women's Health
Background:
- Vasomotor symptoms (VMS) significantly impact quality of life.
- Current treatments for VMS have limitations.
- Neurokinin (NK) receptor antagonists target thermoregulatory pathways.
Purpose of the Study:
- To evaluate NK receptor antagonists for VMS treatment.
- To compare selective NK3 and dual NK1/NK3 antagonists.
- To assess safety and additional benefits like sleep improvement.
Main Methods:
- Clinical trials evaluating fezolinetant and elinzanetant.
- Assessment of VMS frequency and severity.
- Evaluation of sleep quality and safety profiles.
Main Results:
- Both fezolinetant and elinzanetant demonstrated rapid and significant VMS reduction.
- Elinzanetant showed additional benefits in sleep quality.
- Favorable safety profiles were observed for both agents.
Conclusions:
- NK receptor antagonists are a promising nonhormonal VMS treatment.
- Elinzanetant offers dual benefits for VMS and sleep.
- Elinzanetant is suitable for women undergoing endocrine therapy for breast cancer.
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