Alcohol-based microextraction of Rhodamine 6G from soft drink, food, and cosmetic samples

By using alcohol-based solvent extraction without tetrahydrofuran, a liquid-liquid microextraction technique was developed for the separation-enrichment of trace levels of Rhodamine 6G from complex matrices, including soft drinks, food, cosmetics, hygiene products, and natural waters. Numerous experimental parameters were tuned, including pH, alcohol volume, ultrasonication time, and sample and eluent volume. The enrichment factor (EF), limit of detection (LOD), and limit of quantification (LOQ) were used to assess the analytical performance of the suggested approach. The LOD and LOQ were 6.92 ng mL^-1 and 23 ng mL^-1, respectively, and the EF was 14. Through the use of the standard addition method, the proposed alcohol-based solvent extraction method was effectively employed to determine trace amounts of Rhodamine 6G, particularly in soft drinks, cosmetics, hygiene products, food, and natural waterways. High-performance liquid chromatography with fluorescence detection was also used to validate the method in real samples. The suggested method offers a more straightforward extraction process, less solvent consumption, and quick analyte recovery when compared to previously published extraction techniques, underscoring its potential as a useful and ecofriendly substitute for Rhodamine 6G determination.