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Three Dimensional Biomimetic Liver Models to Reconstitute Metabolic Dysfunction-Associated Steatohepatitis (MASH) In
Saeedeh Zare Jalise1,2, Sina Habibi3, Fateme Alizadeh1,2
1Student Research Committee, Qom University of Medical Sciences, Qom, Iran.
Journal of Clinical and Experimental Hepatology
|July 28, 2026
Summary
New in vitro liver models aid in understanding metabolic dysfunction-associated steatohepatitis (MASH). These advanced bioengineered platforms help researchers study disease mechanisms and develop novel therapies for MASH.
Area of Science:
- Hepatology
- Biotechnology
- Drug Discovery
Background:
- Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disease with limited treatment options.
- Current understanding of MASH pathogenesis is hampered by the limitations of traditional research models.
- There is a critical need for advanced in vitro models that accurately recapitulate liver physiology and MASH pathology.
Purpose of the Study:
- To review recent advancements in in vitro liver models for MASH research.
- To highlight the potential of these models in understanding MASH pathogenesis and evaluating therapeutics.
- To discuss the applications of these models in drug discovery, toxicity assessment, and personalized medicine.
Main Methods:
- Exploration of biomimetic three-dimensional cultures.
- Review of microfluidic liver-on-a-chip systems.
- Analysis of liver organoids and scaffold-based approaches.
Main Results:
- These advanced models partially recapitulate key MASH features like lipid accumulation, inflammation, and fibrosis.
- The models facilitate investigation into signaling pathways and molecular mechanisms of MASH.
- The reviewed models offer improved platforms for studying disease progression and therapeutic responses.
Conclusions:
- Bioengineered in vitro liver models represent a significant advancement in MASH research.
- These models hold promise for identifying new therapeutic targets and developing effective MASH treatments.
- The development and application of these platforms are crucial for the future of liver disease management.
