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Multimodal Study of Murine Cardiovascular Remodeling: Four-Dimensional Ultrasound and Mass Spectrometry Imaging
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Beyond biochemistry: multiparametric ultrasound parameters and their molecular correlates in cardio-renal-metabolic

Marcin L Kutek1,2,3, Jacek M Witkowski1

  • 1Department of Embryology, Medical University of Gdańsk, Gdańsk, Poland.

Acta Biochimica Polonica
|July 29, 2026
PubMed

Insights

Multiparametric ultrasound offers a non-invasive method to assess cardio-renal-metabolic syndrome (CRMS) by integrating multiple organ assessments. This approach shows promise for clinical use, pending further validation in prospective trials.

Area of Science:

  • Cardiology
  • Nephrology
  • Metabolic Syndrome
  • Medical Imaging
  • Biomarkers

Background:

  • Cardio-renal-metabolic syndrome (CRMS) involves visceral adiposity, insulin resistance, chronic kidney disease (CKD), and cardiovascular disease (CVD).
  • Assessing the multi-organ burden of CRMS non-invasively at the point of care remains challenging.
  • Established molecular markers often fail to capture the full spectrum of CRMS.

Purpose of the Study:

  • To evaluate multiparametric ultrasound as an integrated imaging biomarker set for CRMS assessment.
  • To determine if ultrasound can complement existing molecular markers for CRMS.
  • To review evidence on ultrasound's utility in assessing components of CRMS.

Main Methods:

  • Narrative literature search of PubMed (2015-2026) using PICO-structured queries.
  • Analysis of studies correlating ultrasound parameters with metabolic, renal, and cardiovascular markers.
  • Review of evidence on hepatic, epicardial, carotid, and renal ultrasound applications in CRMS.

Main Results:

  • Hepatic ultrasound parameters correlate with insulin resistance and liver disease markers.
  • Epicardial adipose tissue thickness is linked to inflammation and diastolic dysfunction.
  • Carotid intima-media thickness and renal resistive index predict CKD progression and cardiovascular events.
  • Renal shear wave elastography shows high accuracy in detecting kidney fibrosis.

Conclusions:

  • Multiparametric ultrasound shows potential as a feasible, integrated biomarker for CRMS.
  • Composite ultrasound-biochemistry models outperform single-parameter assessments.
  • Further prospective trials are needed to validate specific ultrasound values against CRMS stages and establish multiorgan protocols.

Keywords:
cardio-renal-metabolic syndromecarotid intima-media thicknesselastographyepicardial adipose tissuemultiparametric ultrasound

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