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Risk stratification-based tiered medication therapy management for outpatients with asthma: a practical prospective
Yufei Lian1, Shujuan Xiong2, Haijing Zhao3
1Key Laboratory of Clinical Pharmacy of Hebei Province, Department of Pharmacy, Hebei Provincial People's Hospital, Shijiazhuang, Hebei, China.
Frontiers in Pharmacology
|July 30, 2026
Summary
A new tiered medication therapy management (MTM) model improved asthma care outcomes. This risk-stratified approach enhanced clinical, economic, and humanistic values for patients and improved pharmacist efficiency.
Area of Science:
- Clinical Pharmacy
- Health Services Research
- Pharmacoeconomics
Background:
- Asthma management requires effective medication therapy management (MTM).
- Current MTM services may not optimally stratify patient risk or resource allocation.
- A novel tiered MTM approach could enhance outpatient asthma care.
Purpose of the Study:
- To explore and evaluate a new model of tiered MTM services for outpatients with bronchial asthma.
- To assess the multidimensional value (economic, clinical, humanistic) of this T-MTM model using the ECHO framework.
Main Methods:
- A single-center, prospective, randomized controlled, open-label study involving 126 asthma patients.
- Patients were divided into an observation group (T-MTM services) and a control group (traditional MTM services).
- Comparison of economic, clinical, and humanistic outcomes before and after intervention.
Main Results:
- The T-MTM group showed significantly superior economic, clinical (ACT score, adherence), and humanistic outcomes post-intervention (p < 0.05).
- Cost-utility ratio improved, and asthma control scores exceeded the minimum clinically important difference.
- Pharmacist efficiency increased by ~35%, with reduced service time per patient.
Conclusions:
- Risk-stratified tiered MTM services effectively improve pharmacist efficiency and patient outcomes in asthma care.
- This model optimizes pharmacy service resources and enhances patient self-management.
- The T-MTM model is a valuable, promotable modification for outpatient asthma pharmacy services.
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