Enhanced signal discrimination for mixture analysis using SABRE hyperpolarised benchtop 1H NMR spectroscopy
Gregory J Yule1, Daniel A Taylor1, Jonathan Hedges2
1Department of Chemistry, University of York, Heslington, York, North Yorkshire, YO10 5DD, UK. meghan.halse@york.ac.uk.
None:
1H benchtop NMR spectroscopy provides a more accessible alternative to high-field NMR but suffers from lower sensitivity and increased peak overlap. Here, we overcome these challenges by combining SABRE hyperpolarisation with homonuclear decoupling and ultra-selective pulse sequences. The efficacy of this approach is demonstrated for a mixture of analytes, where the 700-fold signal enhancement provided by SABRE enables the acquisition of a well-resolved homodecoupled 1H benchtop NMR spectrum, along with sub-spectra for each component, extracted from a region of significant peak overlap.
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