Related Experiment Video

Updated: Aug 8, 2026

Tropomodulin 3 Overexpression as a Marker for Platinum Resistance and Immune Infiltration in Ovarian Cancer
09:40

Tropomodulin 3 Overexpression as a Marker for Platinum Resistance and Immune Infiltration in Ovarian Cancer

Published on: August 2, 2024

DUSP5 contributes to platinum resistance in ovarian cancer: single-cell discovery and functional validation

Chengfeng Liu1, Wehua Li2, Tingjun Liao3

  • 1Department of Oncology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, China.

Frontiers in Pharmacology
|August 7, 2026
PubMed
Abstract

Insights

DUSP5 influences platinum response and resistance in ovarian cancer by linking tumor adaptation to the tumor microenvironment. This suggests DUSP5 is a potential biomarker and therapeutic target for improving chemotherapy efficacy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Platinum-based chemotherapy is standard for ovarian cancer but faces acquired resistance.
  • Understanding platinum resistance mechanisms, including tumor microenvironment (TME) interactions, is crucial for therapeutic success.

Purpose of the Study:

  • To investigate the cellular and molecular mechanisms underlying platinum sensitivity and resistance in ovarian cancer.
  • To identify key regulators of tumor adaptation and TME interactions in response to chemotherapy.

Main Methods:

  • Integrated single-cell RNA-seq and bulk multi-omics data from ovarian tumors.
  • Analyzed epithelial heterogeneity, transcriptional changes, immune infiltration, and cell-cell communication.
  • Performed functional validation of DUSP5 using knockdown and various in vitro/in vivo assays.

Main Results:

  • Chemotherapy induced epithelial states with stress, EMT, hypoxia, and inflammatory signatures.
  • Elevated DUSP5 expression correlated with specific signaling pathways, immune infiltration, and clinical outcomes.
  • DUSP5 depletion reduced tumor cell proliferation, migration, and enhanced carboplatin sensitivity, inhibiting xenograft growth.

Conclusions:

  • DUSP5 links tumor-intrinsic adaptive programs to TME features, impacting platinum response and resistance in ovarian cancer.
  • DUSP5 is a potential biomarker for predicting platinum response and a therapeutic target for overcoming resistance.
Keywords:
DUSP5multi-omics integrationovarian cancerplatinum resistanceprecision oncologytherapeutic targettumor microenvironment

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