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Updated: Aug 9, 2026
06:05
The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time
Published on: February 19, 2021
Process Intensification, Powered by Collaboration: Poster Presented at PDA Week 2026
Christopher J Hall1, Mark Schofield2, Kurt Boenning2
1PAK BioSolutions christopher.hall@pakbiosolutions.com.
PDA Journal of Pharmaceutical Science and Technology
|August 7, 2026
Summary
Continuous biomanufacturing accelerates biologics production. Strategic collaboration enables rapid deployment of downstream processing using advanced technologies for scalable, cost-efficient manufacturing.
Area of Science:
- Biotechnology and Bioprocessing
- Chemical Engineering
Background:
- Growing demand for biologics necessitates scalable and cost-efficient manufacturing solutions.
- Traditional batch biomanufacturing faces challenges in meeting global demand.
- Continuous biomanufacturing offers advantages in scalability, flexibility, and cost-efficiency.
Purpose of the Study:
- To demonstrate the rapid deployment of continuous downstream processing using commercially available technologies.
- To showcase the integration and automation of unit operations through a strategic collaboration.
- To highlight the simplification and control of continuous processing workflows.
Main Methods:
- Utilized the PAK Pilot system for orchestration and integration of unit operations.
- Implemented ÄKTA pcc continuous chromatography system with MabSelect PrismA and Capto adhere resins.
- Integrated continuous low pH virus inactivation and virus filtration steps.
Main Results:
- Successfully demonstrated a connected, continuous downstream processing workflow.
- Showcased reduced development and operation time for interconnected processes.
- Highlighted seamless control and simplification of continuous processing workflows.
Conclusions:
- The collaboration between Cytiva and PAK BioSolutions provides a practical and scalable path to continuous biomanufacturing.
- Commercial technologies can be effectively integrated for efficient and manageable continuous processing.
- This approach transforms complex biomanufacturing into an efficient reality.
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