Related Experiment Video

Updated: Aug 9, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
08:43

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives

Published on: January 19, 2016

α‑Fluoronitroalkenes as Fluorinated Building Blocks: Solvent-Controlled Functionalization with Hydrazones

Matthew A Saucier1, Hamdan Alrefaei1,2, Peggy A McCluggage1

  • 1Department of BioMolecular Sciences, University of Mississippi, University, Mississippi 38677, United States.

ACS Organic & Inorganic Au
|August 8, 2026
PubMed
Summary

Researchers developed a new method for forming C-N bonds using alpha-fluoronitroalkenes and hydrazones. Reaction conditions control whether N-fluoroalkyl hydrazones or 4-fluoropyrazoles are formed, expanding synthetic possibilities.

Keywords:
1,3-cycloaddition1,4-conjugate addition4-fluoropyrazolesN-fluoroalkyl hydrazonesfluorinated building blockssolvent controlα-fluoronitroalkenes

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