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Hair bulb and oral mucosa DNA for prompt germline testing in hematologic neoplasms

Ferran Balbastre-Úbeda1, Sara Torres-Esquius1, Maria Gabarrós-Subirà1

  • 1Myeloid Malignancies Research Group, Vall d'Hebron Institute of Oncology (VHIO), Hematology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

Blood Cancer Journal
|August 11, 2026
PubMed
Abstract

No abstract available in PubMed .

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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...

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