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Identification of Two Novel HLA-C Alleles, HLA-C*01:284 and HLA-C*01:296

Qi Li1, Ying Li1, Lina Dong1

  • 1HLA Typing Laboratory, Blood Center of Zhejiang Province, Hangzhou, China.

HLA
|August 12, 2026
PubMed

Abstract:

Compared with HLA-C*01:02:01:01, the alleles HLA-C*01:284 and HLA-C*01:296 each show one nucleotide substitution, respectively.

Keywords:
HLA‐C*01:284HLA‐C*01:296HLA‐C

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

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