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Identification of the Novel HLA-DRB4*01:01:13 Allele in a Chinese Individual

Yizhen He1, Lina Dong1, Qi Li1

  • 1HLA Typing Laboratory, Blood Center of Zhejiang Province, Hangzhou, China.

HLA
|August 26, 2026
PubMed

Keywords:
HLA‐DRB4*01:01:13next‐generation sequencingnovel allele

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The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...