MiREDiBase: A Comprehensive Resource for miRNA Editing Events

MicroRNA (miRNA) editing introduces a new layer of complexity in post-transcriptional gene regulation, with potential implications for miRNA biogenesis, target specificity, and function. However, the lack of a dedicated repository to comprehensively catalog miRNA editing events has hindered advances in the field. MiREDiBase addresses this gap by offering a meticulously curated database focused exclusively on validated, high-confidence putative miRNA editing events, with emphasis on A-to-I (adenosine-to-inosine) and C-to-U (cytidine-to-uridine) editing. This resource provides extensive annotations, including genomic locations, structural changes, and biological context, alongside tools for comparative analysis and predictive modeling of miRNA editing effects. MiREDiBase integrates data from experimental validation and high-throughput sequencing, delivering insights into the functional and pathological significance of miRNA editing across species. Unique features include a user-friendly interface for searching and comparing editing patterns, access to RESTful APIs for advanced data retrieval, and integration with external databases to enhance usability in epitranscriptomics research. By bridging the gap between RNA editing and miRNA research, MiREDiBase fosters innovative exploration of miRNA biology, advancing our understanding of its role in health and disease.