Related Experiment Video
Updated: Sep 23, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
ESIC Series: Paper 7 Capacity sharing in Evidence Synthesis: Recommendations from the Evidence Synthesis
Edward Kayongo1, Getahun Fetensa2, Justine Germo Nzweundji-Khumbah3
1Makerere University, Kampala, Uganda.
Aim:
To develop actionable recommendations for capacity sharing as a core enabler of a sustainable global evidence synthesis ecosystem.
Background:
The Evidence Synthesis Infrastructure Collaborative (ESIC), launched in 2024 with Wellcome Trust support, seeks to strengthen evidence synthesis methods, capacity, and infrastructure worldwide. Working Group 5 (WG5) focused on capacity sharing-defined as the equitable, reciprocal exchange of skills, knowledge, and resources-moving beyond traditional unidirectional capacity-building models to foster inclusive, collaborative approaches.
Methods:
WG5 employed a two-phase, four-stage process informed by the Double Diamond design framework. Phase 1 mapped existing capabilities and gaps through a Capability Maturity Assessment (CMA) across regions. Phase 2 identified and prioritised solutions via iterative consultations, literature reviews, expert feedback, and alignment with other ESIC working groups. 20 participants from 22 countries contributed, ensuring diverse representation.
Results:
The CMA revealed stark disparities: high-income regions exhibited mature systems, while many LMICs lacked mechanisms for sustained collaboration. Barriers included fragmented digital infrastructure, skills gaps, weak mentorship, limited knowledge translation, and insufficient end-user engagement, with language as a cross-cutting challenge. WG5 proposed a portfolio of ten interlinked solutions, including an ESIC Knowledge Hub, AI-powered knowledge translation tools, regional collaborating centres, mentorship programmes, continuous professional development modules, and competency frameworks. These solutions aim to rebalance inequities, enhance efficiency, and foster south-led innovation.
Conclusion:
WG5's recommendations provide a scalable, costed roadmap to embed equity and co-creation in global evidence synthesis. By integrating digital tools, human infrastructure, and participatory governance, the proposed portfolio offers funders and stakeholders a menu of options to transform a fragmented system into a connected, inclusive, and resilient evidence ecosystem.
Related Concept Videos
Inductive Effects on Chemical Shift: Overview
Electrospray Ionization (ESI) Mass Spectrometry
ESI utilizes electrical energy to transfer ions from the liquid phase of the sample into the...
Dose-Response Relationship: Potency and Efficacy
Hazard Ratio
For example, in a clinical trial evaluating a...
Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview
Structure and Nomenclature of Ethers
Ethers are organic compounds with an ether functional group which is characterized by an oxygen atom connected to two — identical or different — alkyl, aryl, or vinyl groups. The C–O–C linkage in dimethyl ether — the simplest ether — has an approximately tetrahedral bond angle of 110.3 degrees. The oxygen atom is sp3- hybridized, with the C–O distance being about 140 pm.
Classification of Ethers
Based on their attached substituent groups, ethers can be classified into two...