[A Study on Influence of Hematocrit on Platelet Yield]

To investigate the influence of hematocrit (HCT) on platelet yield.

Retrospective analysis was conducted on data from apheresis donors from January to February 2024, including height, weight, HCT, pre-donation platelet (pre-PLT) count, processed blood volume, collection duration. Differences in HCT, processed blood volume, and collection duration among platelet concentrate with varying counts were compared.

The qualification rates of single-unit, 1.5-unit, and double-unit PLT products were 100%, 83.94% and 94.09%, respectively, which exceeded the national standard (qualification rate should not be lower than 75%). The factors influencing the PLT yield were HCT, body weight and pre-PLT count. 50% of double-unit platelet products had counts exceeding 1 101×10⁹/L, while the remaining 50% fell within the range of 985×10⁹/L to 1 100×10⁹/L. Under equivalent height, weight, and pre-PLT count conditions, when HCT was 44%, double-unit platelet concentrate counts met the standard, with reduced processing blood volume and collection time compared to over-standard products.

HCT is one of the critical factors influencing platelet yield. For double-unit apheresis, adjusting HCT to no lower than 44% in donors with high HCT ensures compliance with product quality standards while maintaining donor safety, particularly for individuals with low body weight, poor blood flow, or susceptibility to donation reactions.