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Identification of Two Novel HLA-B Alleles by Next-Generation Sequencing: HLA-B*52:01:64 and HLA-B*07:561

Sureka Rajendran1, Sandeep Sivakumar1, Kanaga Ganesan1

  • 1Molecular Genetics Division, Lifecell International Pvt Ltd, Chennai, Tamil Nadu, India.

HLA
|September 29, 2026
PubMed

Keywords:
HLA‐Bnext generation sequencingnovel allele

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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