Related Experiment Video
Updated: Oct 15, 2026

Two-photon Imaging of Cellular Dynamics in the Mouse Spinal Cord
Published on: February 22, 2015
Imaging of Congenital Anomalies of the Spinal Cord: Part 2
Vivek Pai1, Pradeep Krishnan1, Elka Miller1
1Division of Neuroradiology, Department of Diagnostic and Interventional Radiology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Department of Medical Imaging, Temerty Faculty of Medicine, University of Toronto, 263 McCaul Street, 4th floor, Toronto, ON M5T 1W7, Canada.
Abstract:
Closed spinal dysraphisms without a subcutaneous mass comprise diverse congenital anomalies arising from disrupted primary or secondary neurulation, often presenting with subtle clinical features yet significant long-term neurologic, orthopedic, and urologic morbidity. Pathophysiology frequently involves intrinsic cord maldevelopment or tethered cord syndrome. Imaging, particularly MR imaging, is central to diagnosis, enabling categorization into simple (eg, intradural lipoma, filum terminale lipoma, and persistent terminal ventricle) and complex lesions (eg, dermal sinus tract, neurenteric cyst, split cord malformation, and segmental spinal dysgenesis). Recognition of embryologic mechanisms and characteristic imaging patterns is critical for accurate diagnosis, risk stratification, and guiding neurosurgical management.
Related Concept Videos
Spinal Cord: Cross-sectional Anatomy
Gray Matter and its Components
Central to the gray matter is...
Spinal Cord: Gross Anatomy
Secondary Spinal Cord Injury llI: Pathophysiology
Spinal Nerves: Anatomy
There are 31 bilateral pairs of spinal nerves, each emerging from the spinal cord through the intervertebral foramina—openings between adjacent vertebrae. These nerves are...
Spinal Cord Injury ll: Pathophysiology
Imaging Studies III: Computed Tomography
