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Choroidal vascularity index changes in proliferative and nonproliferative macular telangiectasia type 2
Zeynep Eylul Ercan1, Gulsah Gokgoz2, İmren Akkoyun2
1Department of Ophthalmology, Yıldırım Beyazıt University Yenimahalle Education and Training Hospital, Ankara, Turkey.
Purpose:
This study aimed to evaluate the choroidal vascularity index (CVI) in patients with nonproliferative and proliferative macular telangiectasia type 2 (MacTel-2) compared to healthy controls, assess the impact of ellipsoid zone (EZ) disruption on CVI, and determine whether CVI measurements vary with different binarization areas.
Materials And Methods:
CVIs from MacTel-2 eyes were compared to those of healthy controls. MacTel-2 eyes were categorized as proliferative or nonproliferative and further subdivided by the presence or absence of EZ disruption. CVI was measured in three regions: 1500 µm, 4000 µm, and the total macular choroidal area (TCA). Statistical analyses included paired samples t-tests, independent samples t-tests, and Mann-Whitney U-tests. P < 0.05 was considered statistically significant.
Results:
This study included 90 eyes each from MacTel-2 patients and healthy controls. CVIs did not significantly differ between eyes with and without EZ disruption in either MacTel-2 group (P > 0.05). CVIs beneath EZ-disrupted areas were also comparable to intact zones (P > 0.05). No significant CVI difference was observed between nonproliferative and proliferative MacTel-2 eyes (P > 0.1). However, both the groups had significantly lower CVIs than healthy controls across all measured areas (P < 0.001 for nonproliferative and P < 0.05 for proliferative). CVI values were consistent across all binarization areas (P > 0.1).
Conclusion:
EZ disruption does not affect CVI. CVIs were similar in nonproliferative and proliferative MacTel-2, both lower than in healthy eyes. CVI also remained consistent across different binarization areas, confirming its reliability regardless of area size.
