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Updated: Oct 25, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Palladium-Catalyzed Allylic C(sp3)-H Amidative Annulation of Indene: Access to Spirocyclic N-Heterocycles
Pei-Jun Yang1,2, Hao Liu1, Bing-Yi Liu2
1Anhui Province Key Laboratory of Functional Coordinated Complexes for Materials Chemistry and Application, School of Chemical and Environmental Engineering, Anhui Polytechnic University, Middle Beijing Road, Wuhu, Anhui241000, China.
Abstract:
N-Heterocycles are a class of pivotal values in diverse fields, and methods for their efficient construction are highly desired. Herein, we report a palladium-catalyzed allylic C(sp3)-H amidative annulation of indene, accessing spiro[indene-1,2'-pyrrolidine] derivatives with tetrasubstituted stereogenic centers. Optimized conditions afford good-to-excellent yields (up to 91%) with broad substrate tolerance. Gram-scale synthesis and further derivatizations demonstrate the synthetic utility of the reaction.
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