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Chemoselective Preparation of 1-Iodoalkynes, 1,2-Diiodoalkenes, and 1,1,2-Triiodoalkenes Based on the Oxidative Iodination of Terminal Alkynes
Published on: September 12, 2018
Visible-Light-Induced Stereoselective Radical 1,3-Iodosulfonylation of Methylenecyclopropanes
Jie Huang1, Lanqin Liu1, Zijie Zhang1
1School of Chemistry & Materials, Jiangsu Provincial Key Laboratory of Green & Functional Materials and Environmental Chemistry, Yangzhou University, Yangzhou225002, China.
Abstract:
We report herein a visible-light-promoted strain-release-enabled regio- and stereoselective radical 1,3-iodosulfonylation protocol for the synthesis of alkyl iodide-containing alkenyl sulfone compounds. The use of unactivated methylenecyclopropanes (MCPs) as radical acceptors was crucial for the present cascade radical difunctionalization process via a formal C-C bond cleavage under ambient temperature and transition-metal-free reaction conditions.
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