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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Nickel-Catalyzed Diastereoselective Cascade Cyclization/Cross-Coupling for the Synthesis of Dibenzazepines
Shijun Liu1, Keyong Zhu1, Peng Yan1
1Central Hospital of Dalian University of Technology, School of Chemistry, Dalian University of Technology, Dalian, Liaoning116024, China.
Abstract:
Here, we report a nickel-catalyzed system for intramolecular cascade cyclization/cross-coupling, affording diverse dibenzazepines with exclusive diastereoselectivity. Reversible dissociation of a labile ligand generates an open coordination site, enabling alkene binding and a key eight- to nine-membered nickelacycle transition state, supported by DFT calculations. The method features broad substrate scope and good functional group tolerance and provides straightforward access to dibenzazepines.
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