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Accelerating Science with Human+AI Review

Arjun K Manrai1,2, David Ouyang2,3, Joseph W Hogan2,4

  • 1Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.

NEJM AI
|October 26, 2026
PubMed

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Non-equilibrium in the Cell01:16

Non-equilibrium in the Cell

An important concept in studying metabolism and energy is that of chemical equilibrium. Most chemical reactions are reversible. They can proceed in both directions, releasing energy into their environment in one direction, and absorbing it from the environment in the other direction. The same is true for the chemical reactions involved in cell metabolism, such as the breaking down and building up of proteins into and from individual amino acids, respectively. Reactants within a closed system...