[Renin-angiotensin-aldosterone system in acute embologenic arterial obstruction]

Examination of patients with acute embologenic arterial occlusion yielded data testifying to activation of the renin-angiotensin-aldosterone system both in the ischemic and in the postischemic periods. Direct dependence of the activation of the renin-angiotensin-aldosterone system on the degree of tissue ischemia and duration of the ischemic period of up to 2 days was revealed. The development of secondary hyperaldosteronism in patients with embolism of the major vessels stipulated the expediency of using aldosterone antagonists in patients with most marked ischemic changes in the tissues as well as when the ischemic period lasted more than 6 hours.