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Related Experiment Videos

Methotrexate for psoriasis-revisited.

M N O'Donoghue, R E Melcher

    American Family Physician
    |April 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Methotrexate therapy is a viable option for severe psoriatic arthritis when other treatments fail and systemic steroids are not advised. This treatment requires a normal liver biopsy and careful administration for optimal results.

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    Area of Science:

    • Dermatology
    • Rheumatology
    • Pharmacology

    Background:

    • Psoriatic arthritis is a chronic inflammatory condition impacting joints and skin.
    • Maximum medical management may include hospitalization, tar and sunlight therapy, and topical steroids with occlusion.
    • Photochemotherapy (PUVA) is an alternative treatment option.

    Observation:

    • When standard treatments and PUVA are unavailable or ineffective, alternative therapies are necessary.
    • Systemic steroids may be inadvisable for certain patients.
    • Patient history, including liver function and alcohol consumption, is crucial for treatment selection.

    Findings:

    • Methotrexate therapy is recommended for severe psoriatic arthritis unresponsive to other treatments.
    • It is particularly indicated when systemic steroids are contraindicated.

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  • A normal liver biopsy and absence of excessive alcohol intake are prerequisites for methotrexate use.

    • Implications:

    • Methotrexate offers an alternative treatment for severe psoriatic arthritis.
    • Careful patient selection and monitoring are essential for safe and effective methotrexate use.
    • Specific dosing regimens, such as three divided doses every 12 hours weekly, may optimize efficacy and minimize toxicity.