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Contamination of Pantopaque by glass
Surgical Neurology
|April 1, 1979
Summary
Glass fragments can contaminate Pantopaque during ampule opening and may be injected into the spinal canal. A 0.22 micron Millex filter effectively removes these glass particles from Pantopaque.
Area of Science:
- Neurosurgery
- Radiology
- Materials Science
Background:
- Pantopaque, a contrast agent used in spinal procedures, may become contaminated with glass fragments during ampule opening.
- The potential risks of injecting these glass fragments into the spinal subarachnoid space are currently unknown.
Purpose of the Study:
- To investigate the potential contamination of Pantopaque with glass fragments.
- To identify a method for removing glass contaminants from Pantopaque before injection.
Main Methods:
- Analysis of Pantopaque after ampule opening to detect glass fragments.
- Evaluation of a 0.22 micron Millex filter for its efficacy in removing glass particles from Pantopaque.
Main Results:
- Variable amounts of glass fragments were observed in Pantopaque after opening ampules.
- Passing Pantopaque through a 0.22 micron Millex filter successfully removed glass fragments.
Conclusions:
- Glass contamination of Pantopaque is a potential risk during clinical use.
- Filtration using a 0.22 micron Millex filter is an effective method to ensure the purity of Pantopaque for spinal injections.