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Electron microscopical studies on onchocerciasis. III. The onchocerca-nodule
Tropenmedizin Und Parasitologie
|March 1, 1979
Summary
Electron microscopy revealed diverse immune cells within onchocerca nodules, including differentiating lymphocytes and degenerating macrophages. This study details the cellular composition and ultrastructure of Onchocerca volvulus nodules from Liberian patients.
Area of Science:
- Pathology
- Parasitology
- Cell Biology
Background:
- Onchocerca volvulus causes onchocerciasis, a neglected tropical disease.
- Nodules are a hallmark of onchocerciasis, containing the adult worms and eliciting host immune responses.
Purpose of the Study:
- To characterize the cellular infiltrate and ultrastructure of onchocerca nodules.
- To examine the developmental stages of microfilariae within the adult worm.
Main Methods:
- Electron microscopy was used to examine six onchocerca nodules from five Liberian patients.
- Detailed ultrastructural analysis of cellular components and parasite morphology was performed.
Main Results:
- Nodule centers were rich in lymphocytes and macrophages, with macrophages showing degenerative changes.
- Epithelioid cells and giant cells were observed near the worms.
- The ultrastructure of Onchocerca volvulus, including cuticle, hypodermis, intestine, and uterus with developing microfilariae, was detailed.
Conclusions:
- The cellular composition of onchocerca nodules reflects a complex host immune response.
- Electron microscopy provides valuable insights into the parasite's ultrastructure and microfilarial development.