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Mal de Meleda treated with 13-cis retinoic acid
Archives of Dermatology
|May 1, 1979
Summary
Mal de Meleda, a rare genetic skin disorder, causes severe hyperkeratosis. Oral 13-cis retinoic acid effectively treated affected identical twins, showing significant improvement with manageable side effects like cheilitis.
Area of Science:
- Dermatology
- Medical Genetics
Background:
- Mal de Meleda is a rare autosomal recessive genodermatosis.
- Characterized by "glove and sock" hyperkeratosis, hyperhidrosis, and malodor.
- Genetic origin linked to Calabria, Italy, and consanguineous parents.
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