[Pathological anatomy of rubeolar embryo-fetopathy]

The paper describes two cases of congenital rubeolar embryo- and fetopathy which show that in infection with rubella virus in the 1st trimester of pregnancy the virus effect may be limited to the period of embryogenesis or extend to the fetal period as well. In the first instance, multiple developmental defects occur at the organ level; in prolonged virus effect organogenesis disorders are combined with tissue displasias and inflammatory processes, that is, the pathology typical of the fetal period. Congenital rubella is characterized by a subacute course and wide generalization of the alterative-productive inflammation: productive dermatitis, subacute productive-necrotic encephalitis and endophthalmitis, as well as giant-cell metamorphosis of alveolocytes.