Related Experiment Video
Updated: Apr 28, 2026
06:35
An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
6.8K
Summary
Granuloma counts in Crohn's disease predict prognosis in the large bowel and anus, but not the small bowel. Higher granuloma content suggests a better outcome, potentially indicating an adaptive immune response.
Area of Science:
- Gastroenterology
- Immunology
- Pathology
Background:
- Crohn's disease is a chronic inflammatory bowel disease.
- Granulomas are characteristic histological findings in Crohn's disease.
Purpose of the Study:
- To investigate the prognostic significance of granuloma counts in Crohn's disease.
- To explore the relationship between granuloma content, disease location, and clinical history.
Main Methods:
- Quantification of granulomas in bowel sections from Crohn's disease patients.
- Correlation of granuloma counts with clinical parameters: disease history, steroid treatment, site of involvement, and disease course.
Main Results:
- High granuloma content correlated with a good prognosis in the large bowel and anus.
- Granuloma counts had no prognostic value in the small bowel.
- Significant regional variation in granuloma counts observed: small bowel (1), colon (6), rectum (18), anus (36).
- Longer clinical history was associated with lower granuloma content.
Conclusions:
- Granuloma presence may indicate an adaptive immune response in Crohn's disease.
- Granuloma counts offer prognostic information for large bowel and anal Crohn's disease.
- Further research is needed to elucidate the role of granulomas in Crohn's pathogenesis.
Related Concept Videos
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
749
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
749
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
876
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
876
01:30Inflammatory Bowel Disease II: Crohn's Disease
1.6K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.6K
01:12Chronic Inflammation: Introduction
36
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
36
01:25Inflammatory Bowel Disease III: Crohn's Disease
29
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
29
01:20Inflammatory Bowel Disease IV: Clinical Manifestations
30
Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The...
30