[Hepatotoxicity of the lipid components of the lipopolyysaccharides from typhoid bacteria]

Distinct increase in amount of total lipids occurred in mice liver tissue after intraperitoneal administration of typhoid lipids A and B (the latter was nonhydrolytically isolated from typhoid lipopolysaccharides). The alteration referred primarily to neutral lipids, especially to triacyl glycerides, content of which exceeded 3- and more-fold the initial one to the end of a day. The similarity was observed in alteration of triacyl glycerides, phospho- and glycolipids in presence of both lipid preparations. These lipid components resembled intact lipopolysaccharide from typhoid bacteria in their effect on content of lipids in liver tissue. In treatment with these lipid preparations concentration of NEFA was either unaltered or distinctly decreased.