[Effect of typhoid endotoxin on total and neutral lipid content in mouse liver tissue]

Sublethal doses of typhoid lipopolysaccharide increased distinctly the content of total lipids in mice liver tissue. Liver obesity was mainly related to accumulation of triacyl glycerols, the level of which exceeded the initial one 6.2-fold within a day. Mono- and diacyl glycerols also accumulated in liver tissue within the same period. Content of free fatty acids was distinctly higher in experimental animals than in control mice. Pronounced increase in free cholesterol content was observed within 3 hrs after the lipopolysaccharide administration; but within a day the content of cholesterol was markedly lower in the animals as compared with the control mice. The intoxication was accompanied by a decrease in glycolipid content within 3 and 6 hrs but towards the end of the 24-hrs period content of these lipids did not differ from the initial level in liver tissue. The endotoxin did not alter distinctly the total phospholipid content in liver tissue.