[Effect of typhoid endotoxin and lipid A on the phospholipid content in liver tissue]

Content of phospholipid fractions was altered in mice liver tissue after intraperitoneal administration of typhoid lipopolysaccharide and of lipid A, isolated from the lipopolysaccharide. The intoxication was accompanied by an increase in content of choline-containing phospholipids within 6 and 24 hrs as well as by an alteration in the ratio of the fractions. Effect of lipid A on the tissue phospholipid spectra resembled the effect of the lipopolysaccharide, but was less prolonged. The lipopolysaccharide and lipid A altered the stability of phosphatidyl choline and cardiolipin bonds with the components of liver cells.