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The paracellular pathway and bile formation.

J L Boyer, E Elias, T J Layden

    The Yale Journal of Biology and Medicine
    |January 1, 1979
    PubMed
    Summary
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    Bile acids like taurocholate increase invaginations in rat liver cells, suggesting they enhance fluid and electrolyte transport through cell junctions during bile formation.

    Area of Science:

    • Hepatology
    • Cell Biology
    • Gastroenterology

    Background:

    • Bile acids are crucial for digestion and liver function.
    • The paracellular pathway in the liver plays a role in bile formation.
    • Understanding how bile acids affect liver cell structure is important for studying liver diseases.

    Purpose of the Study:

    • To investigate the effect of taurocholate on the ultrastructure of rat liver cells.
    • To explore the relationship between bile acid infusion and the paracellular pathway's conductivity.
    • To determine if bile acids influence fluid and electrolyte transport across hepatocyte junctions.

    Main Methods:

    • Scanning electron microscopy (SEM) was used to observe cell surface changes.
    • Transmission electron microscopy (TEM) was employed to examine cellular morphology.

    Related Experiment Videos

  • Ionic lanthanum chloride was used to trace pathway localization.

    • Main Results:

    • Taurocholate infusions significantly increased lateral cell surface invaginations in rat liver cells.
    • These invaginations resembled osmotic "blisters" and correlated with increased paracellular conductivity.
    • Lanthanum chloride localized within hepatocyte junctional complexes after taurocholate infusion.

    Conclusions:

    • Bile acids, such as taurocholate, induce structural changes in liver cells.
    • These structural changes are associated with increased ionic and hydraulic conductivity of the paracellular pathway.
    • Bile acids may stimulate transcellular fluid and electrolyte movement, contributing to bile formation.