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Studies on monkeypox virus.

C J Rondle, K A Sayeed

    Bulletin of the World Health Organization
    |January 1, 1972
    PubMed
    Summary

    Three monkeypox virus strains showed similar growth patterns and could be differentiated from other poxviruses. Serological tests confirmed monkeypox virus strains are closely related to variola virus.

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    Area of Science:

    • Virology
    • Poxvirus research

    Background:

    • Monkeypox virus is a zoonotic poxvirus with potential public health implications.
    • Understanding the genetic and antigenic diversity of monkeypox virus strains is crucial for diagnostics and vaccine development.

    Purpose of the Study:

    • To characterize the growth properties and serological relationships of three monkeypox virus strains.
    • To differentiate monkeypox virus from other related orthopoxviruses such as variola, vaccinia, and cowpox viruses.

    Main Methods:

    • Cultivation of monkeypox virus strains on chick chorioallantoic membrane and in RK13 cells.
    • Inoculation of rabbit dermis to assess growth characteristics.
    • Serological analysis using haemagglutination-inhibition and neutralization tests with homologous and heterologous antisera.

    Main Results:

    • All three monkeypox virus strains exhibited indistinguishable growth characteristics and plaque formation.
    • Monkeypox virus strains could be differentiated from vaccinia and cowpox viruses by cultural and serological methods.
    • Serological tests indicated a closer relationship between monkeypox and variola viruses compared to vaccinia and cowpox viruses.

    Conclusions:

    • The studied monkeypox virus strains represent a homogeneous poxvirus entity.
    • Cultural characteristics effectively differentiate monkeypox virus from other poxviruses.
    • Serological data suggest a close antigenic relationship between monkeypox and variola viruses.

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