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Effect of a Millipore filter on complications of intravenous infusions: a prospective clinical trial
Abstract:
The Millipore filter unit has been advocated as a means of reducing the chance of bacteria entering the circulation during intravenous infusion. In a prospective study no significant reduction was obtained in the incidence of thrombophlebitis or in the bacterial contamination of cannulae. The unit was inconvenient to use and in-vitro and in-vivo studies showed reduced flow rates and frequent episodes of filter blockage. Its use was further restricted by the fact that blood and fat emulsions would not pass through it.
Insights
The Millipore filter unit did not reduce bacterial contamination or thrombophlebitis during intravenous infusions. This filter also caused flow issues and blockages, limiting its clinical use.
Area of Science:
- Medical Devices
- Infection Control
- Intravenous Therapy
Background:
- Intravenous (IV) infusions can introduce bacteria into circulation.
- Millipore filter units were proposed to mitigate this risk.
- Thrombophlebitis is a common complication of IV therapy.
Purpose of the Study:
- To evaluate the efficacy of Millipore filter units in reducing bacterial contamination during IV infusions.
- To assess the impact of Millipore filters on the incidence of thrombophlebitis.
- To determine the practical usability and performance of the filter units.
Main Methods:
- A prospective study was conducted to assess filter performance.
- In-vitro and in-vivo experiments were performed.
- Bacterial contamination of cannulae and thrombophlebitis incidence were monitored.
Main Results:
- No significant reduction in thrombophlebitis or cannula bacterial contamination was observed.
- The filter units demonstrated inconvenient handling and reduced flow rates.
- Frequent filter blockages and incompatibility with blood/fat emulsions were noted.
Conclusions:
- Millipore filter units are ineffective in preventing bacterial contamination during IV infusions.
- The filters present significant practical limitations and performance issues.
- Their use in routine intravenous therapy is not recommended due to these drawbacks.