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Electrode sensitive to sulfa drugs.

N Hazemoto, N Kamo, Y Kobatake

    Journal of Pharmaceutical Sciences
    |March 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    A novel iron(II)-bathophenanthroline chelate electrode offers rapid and selective detection of sulfa drugs like sulfamerazine and sulfisomidine. This advancement minimizes interference from common interfering substances in analysis.

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    Area of Science:

    • Electroanalytical Chemistry
    • Chemical Sensors
    • Pharmaceutical Analysis

    Background:

    • Traditional colorimetric analysis of sulfa drugs can be affected by interfering substances.
    • Development of selective and rapid detection methods for sulfa drugs is crucial for pharmaceutical quality control.

    Purpose of the Study:

    • To construct and evaluate a novel ion-selective electrode for the detection of sulfa drugs.
    • To assess the electrode's response characteristics and selectivity in the presence of potential interferents.

    Main Methods:

    • Fabrication of a liquid membrane electrode incorporating iron(II)-bathophenanthroline chelate.
    • Electrochemical measurements to determine the electrode's response to sulfamerazine and sulfisomidine.
    • Selectivity testing against common interfering compounds such as urea and p-amino-benzoic acid.

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    Main Results:

    • The developed electrode exhibited rapid and Nernstian responses to sulfamerazine and sulfisomidine within the concentration range of 10(-3) to 10(-1) M.
    • High selectivity was achieved, with minimal interference from urea, glycine, aminopyrine, and p-amino-benzoic acid.
    • The electrode demonstrated effective performance in detecting sulfa drugs even in the presence of substances that typically interfere with colorimetric methods.

    Conclusions:

    • The iron(II)-bathophenanthroline chelate-based liquid membrane electrode is a promising tool for the selective and sensitive determination of sulfa drugs.
    • This electrochemical approach offers an alternative to traditional methods, overcoming limitations related to interfering substances.
    • The electrode's performance suggests its potential application in pharmaceutical analysis and quality control.