[Changes in the state of the blood-brain barrier in rats following experimental neurosensitization]

The accumulation and distribution of phosphorus radioisotope was studied in different brain areas of rats. These rats were desensitized by antigens of a whole homologous brain and its separate structures. A certain general tendency towards an accumulation of the brain phosphorus was detected after neurosensitization. Besides, in sensitization by separate structures (brain cortex, cerebellum) the most pronounced changes were in the hematoencephalic barrier (HEB) of the corresponding brain areas are less pronounced in other structures. The paper contains data concerning the function of HEB in animals immunized by the medulla oblongata. The found changes in the barrier mechanisms of the HEB in neurosensitization may be one of the pathogenetical mechanisms of certain diseases accompanied by neuroautoimmune processes.