Hydrodynamic analog model for pharmacokinetics II: critical examination of model and its contribution to...

A comparison of the conventional pharmacokinetic models and the previously proposed hydrodynamic diffusion analog model is presented. A significant result that an n-compartment system can exhibit at best (n - 1) extremum times in the concentration-time plot of the central compartment under appropriate values of physiological parameters is presented. The observation of kinks experimentally in certain physiological-drug systems is thus shown to be amenable to explanation.