Effect of cholinergic drugs on the perilymphatic oxygen tension

The effect of the intravenous injection of cholinergic drugs on perilymphatic oxygen tension (PO2) was measured using the polarographic method in 20 cats. Acetylcholine, pilocarpine and neostigmine produced minimal but statistically significant changes in perilymphatic PO2. Atropine and scopolamine did not influence the PO2 of the perilymphatic space. The reported results show that under normal conditions the cholinergic receptors of the vestibular vessels have little effect on the permeability of arterial PO2.