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[Henoch-Schoenlein purpura (author's transl)]
Deutsche Medizinische Wochenschrift (1946)
|November 2, 1979
Summary
Central nervous system involvement is common in Henoch-Schoenlein purpura (HSP). This study found neurological symptoms are the rule, not the exception, in children with this condition.
Area of Science:
- Pediatric Neurology
- Immunology
- Rheumatology
Background:
- Henoch-Schoenlein purpura (HSP) is a common childhood vasculitis.
- Central nervous system (CNS) involvement in HSP is not well-defined.
Purpose of the Study:
- To investigate the prevalence and characteristics of CNS involvement in children with acute Henoch-Schoenlein purpura.
Main Methods:
- Routine electroencephalogram (EEG) investigations.
- Observation of neurological and psychological symptoms.
- Capillary resistance testing.
- Factor XIII activity assays.
- Immune complex and antibody studies.
- Total serum complement level determination.
Main Results:
- Central nervous system involvement was observed in 13 out of 13 children during the acute phase of Henoch-Schoenlein purpura.
- Reduced capillary resistance was found in 51 of 76 children.
- Reduced factor XIII activity was found in only 6 children.
- Influenza-A virus infection was identified as a trigger in 13 of 28 children.
- Elevated total serum complement levels were found in two-thirds of patients.
Conclusions:
- Central nervous system involvement is a common finding in children with Henoch-Schoenlein purpura.
- Neurological and psychological symptoms should be closely monitored in acute HSP.
- Influenza-A virus may trigger Henoch-Schoenlein purpura in some children.