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Related Experiment Videos

Permeability factor contaminating hyaluronidase preparations.

J C Houck, C M Chang

    Inflammation
    |September 1, 1979
    PubMed
    Summary
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    A novel permeability factor found in testicular hyaluronidase preparations enhances microcirculation. This factor, distinct from hyaluronidase, may explain its therapeutic effects in myocardial infarction.

    Area of Science:

    • Biochemistry
    • Physiology
    • Pharmacology

    Background:

    • Testicular hyaluronidase preparations contain a component that increases microcirculation permeability.
    • This activity has been observed in both crude and purified preparations.

    Purpose of the Study:

    • To characterize the permeability-increasing component in testicular hyaluronidase.
    • To differentiate this component from hyaluronidase itself.

    Main Methods:

    • Isoelectric focusing was used to determine the isoelectric point.
    • Acrylamide gel electrophoresis was employed for separation.
    • Serum inhibition assays were conducted.

    Main Results:

    • The permeability factor exhibited an isoelectric point of 7.4, distinct from hyaluronidase (9.4).

    Related Experiment Videos

  • The factor was successfully separated from hyaluronidase using electrophoresis.
  • The permeability activity was not inhibited by serum.

    • Conclusions:

    • Testicular hyaluronidase contains a distinct permeability factor.
    • This factor's properties differ significantly from hyaluronidase.
    • The factor may mediate the observed protective effects of hyaluronidase in myocardial infarction models.