[Yellow-nail syndrome from d-penicillamine]

Area of Science:

• Dermatology
• Internal Medicine
• Clinical Case Reports

Background:

• Yellow nail syndrome is a rare disorder characterized by a distinct triad of symptoms.
• Key features include onychodystrophy (nail changes), lymphedema, and chronic respiratory tract conditions.
• Nail abnormalities encompass thickening, yellow discoloration, and altered growth patterns.

Observation:

• This report details a specific case of yellow nail syndrome.
• The patient presented with characteristic nail changes and likely lymphedema and respiratory involvement.
• The observed symptoms were attributed to a specific medication exposure.

Findings:

• The study identifies penicillamine as the causative agent for drug-induced yellow nail syndrome.
• The case illustrates the diagnostic challenge and the importance of medication history in YNS.
• Detailed nail changes observed included scleronychia, growth arrest, and discoloration.

Implications:

• This finding expands the understanding of iatrogenic causes of yellow nail syndrome.
• Clinicians should consider drug-induced etiology, particularly penicillamine, in patients with YNS symptoms.
• Early identification and withdrawal of the offending drug may be crucial for management.