Evolution of Leber's miliary aneurysms: a clinicopathological study

The clinical course is described of two genuine cases of the disease of Leber's miliary aneurysms that developed into Coats' disease. Following the issue of the disease in a painful and blind eye, the cases were examined histopathologically. In the first case the transformation into Coats' disease, and subsequently into a painful eye, took six years, in the second case four years. This histopathological examination revealed vascular formations of the superficial corneal stroma of the periphery in the second case. In respect of the retina the presence of neovascularization was observed. Pathological vessels of varying width were also found in the deeper retinal layers. The presence of cholesterol clefts should be regarded rather as a consequence of the chronicity of the case than as being a characteristic feature of the condition.