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Intravaginal contraception with the synthetic progestin, R2010
Contraception
|November 1, 1979
Summary
This study evaluated vaginal rings with norgestrienone for contraception. Bleeding patterns were irregular, and ovulation occurred in 25% of cycles, indicating limited contraceptive efficacy.
Area of Science:
- Reproductive endocrinology
- Pharmacology
- Contraception
Background:
- Vaginal rings offer a potential route for sustained drug delivery.
- Norgestrienone is a progestin with contraceptive properties.
Purpose of the Study:
- To assess the efficacy and hormonal effects of a novel polysiloxane vaginal ring containing norgestrienone.
- To evaluate bleeding patterns and ovulation suppression during treatment.
Main Methods:
- Four women used vaginal rings with 50 mg norgestrienone for three-week cycles.
- Plasma hormone levels (norgestrienone, estradiol, progesterone, gonadotropins) and bleeding patterns were monitored.
- Ovulation and pituitary suppression were assessed across twelve treatment cycles.
Main Results:
- Unsatisfactory bleeding patterns were observed in most cycles.
- Mean plasma norgestrienone concentration was 0.9 ng/ml.
- Ovulation occurred in 25% of cycles, with mild pituitary suppression achieved.
Conclusions:
- The norgestrienone vaginal ring demonstrated limited efficacy in regulating bleeding and suppressing ovulation.
- Further research is needed to optimize progestin-releasing vaginal ring formulations for contraception.
Keywords:
AcneBiologyClinical ResearchContraceptionContraceptive Agents, Female--administraction and dosageContraceptive Agents, Female--analysisContraceptive Agents, Progestin--administraction and dosageContraceptive Agents, Progestin--analysisContraceptive Agents--administraction and dosageContraceptive Agents--analysisDermatitisDiseasesEndocrine SystemEstradiol--analysisEstrogensFamily PlanningFollicle Stimulating Hormone--analysisGonadotropinsGonadotropins, PituitaryHormonesLuteinizing Hormone--analysisMenstruation DisordersOral ContraceptivesPhysiologyProgestational HormonesProgesterone--analysisResearch MethodologyMore Related Videos
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