Lactate kinetics estimated by single injection and continuous infusion of [14C-(U)]-lactate in rats

1 Identical values of the rate of lactate turnover determined with [14C-(U)]-lactate were found with single injection or continuous infusion techniques in anaesthetized and mechanically ventilated rats. 2 The mean transit time and total minimal body mass of lactate determined graphically (Katz et al., 1974 a, b) were higher with single injection than with continuous infusion of the tracer.